ALK5-IN-31 is a selective inhibitor of ALK-5, with an IC50 value of ≤10 nM, that effectively disrupts TGF-β-induced SMAD signaling pathways. This compound demonstrates potential anti-tumor activity in vivo and may be instrumental in the research of proliferative diseases, including cancer, fibrotic disorders, and systemic sclerosis. Its targeted inhibition of ALK-5 makes it a valuable tool for investigating the therapeutic mechanisms in fibrosis and tumorigenesis.
ALK5-IN-31 is a selective inhibitor of ALK-5, with an IC50 value of ≤10 nM, that effectively disrupts TGF-β-induced SMAD signaling pathways. This compound demonstrates potential anti-tumor activity in vivo and may be instrumental in the research of proliferative diseases, including cancer, fibrotic disorders, and systemic sclerosis. Its targeted inhibition of ALK-5 makes it a valuable tool for investigating the therapeutic mechanisms in fibrosis and tumorigenesis.
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