Fig. 1 · Structure
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ALK5-IN-32
ALK-5 Inhibitor
ALK5-IN-32 is a selective inhibitor of ALK-5, exhibiting an IC50 range of 10 nM to 100 nM. This compound effectively inhibits TGF-β-induced SMAD signaling pathways, thereby demonstrating potential in the inhibition of tumor growth in vivo. ALK5-IN-32 is valuable for research into proliferative diseases, including cancer, fibrotic disorders, and systemic sclerosis.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2785430-88-6 |
| Applications | ALK-5 Inhibitor |
| Formula | C23H23FN8 |
| Molecular Weight | 430.48 |
| SMILES | CC1=CC=CC2=C(NC3=NC(NC4=CC=C(N5CCNCC5)C=C4)=NC=C3F)C=NN=C12 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.