Fig. 1 · Structure
Documents & Downloads
ALK5-IN-82
Cat. No.
A84916
CAS
3001361-04-9
ALK5 Inhibitor
ALK5-IN-82 is a potent and selective inhibitor of activin receptor-like kinase 5 (ALK5), demonstrating an IC50 value of 9.1 nM. This compound effectively reduces the expression of α-smooth muscle actin, collagen I, and tissue inhibitor of metalloproteinase 1 in transforming growth factor-β-induced human umbilical vein endothelial cells. ALK5-IN-82 is particularly relevant for the study of cardiac fibrosis and its associated pathways, making it a valuable tool in cardiovascular research applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 3001361-04-9 |
| Applications | ALK5 Inhibitor |
| Formula | C22H19N7OS |
| Molecular Weight | 429.50 |
| SMILES | CC1=NC(C(NC(CNC(CC2=CC=CS2)=O)=N3)=C3C(C=C4)=CN5C4=NC=N5)=CC=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.