Fig. 1 · Structure
Documents & Downloads
ALK5-IN-9
Cat. No.
A84883
CAS
2489611-06-3
ALK5 Inhibitor
ALK5-IN-9 is a potent inhibitor of TGFβRI (ALK5) that effectively disrupts autophosphorylation of the kinase. With an IC50 of 25 nM for ALK5 and 74.6 nM for NIH3T3 cell activity, this compound demonstrates significant biological efficacy. ALK5-IN-9 exhibits a favorable pharmacokinetic profile and reduced hERG inhibition, making it a valuable tool for investigating the role of TGFβ signaling in various cancer research applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2489611-06-3 |
| Applications | ALK5 Inhibitor |
| Formula | C29H35F3N6O3 |
| Molecular Weight | 572.62 |
| SMILES | OCCN1CCN(C2=CC=C(NC3=NC=CC(OC4=CN(C5CC5)N=C4C6CCOCC6)=C3)C=C2C(F)(F)F)CC1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.