Fig. 1 · Structure
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alpha-Hydroxy farnesyl phosphonic acid
Farnesyl Transferase Inhibitor
Alpha-Hydroxy farnesyl phosphonic acid is a nonhydrolyzable analog of farnesyl pyrophosphate that serves as a competitive inhibitor of farnesyl transferase (FTase). It exhibits significant biological activity in inhibiting the processing of Ras in Ha-ras-transformed NIH3T3 cells at concentrations exceeding 1 μM. This compound is valuable for research applications aimed at studying Ras signaling pathways and the implications in oncogenesis.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 148796-53-6 |
| Applications | Farnesyl Transferase Inhibitor |
| Formula | C15H27O4P |
| Molecular Weight | 302.35 |
| Synonyms | Hydroxyfarnesyl phosphate |
| SMILES | C/C(C)=C\CC/C(C)=C/CC/C(C)=C/C(P(O)(O)=O)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.