Fig. 1 · Structure
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AM-8123
APJ Agonist
AM-8123 is a potent orally active APJ agonist that inhibits Forskolin-induced cAMP production while promoting Gα protein activation. This compound is valuable for research applications focusing on cardiovascular diseases, where modulation of the APJ signaling pathway may provide therapeutic insights. Its mechanism and biological activity make AM-8123 an important tool for investigating the role of APJ in cardiovascular health.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 2049973-02-4 |
| Applications | APJ Agonist |
| Formula | C27H33N7O5S |
| Molecular Weight | 567.66 |
| SMILES | CC(C)O[C@@H](C1=NC=C(C)C=N1)[C@H](C)S(NC2=NN=C(C3=CN=CC(C)=C3)N2C4=C(C=CC=C4OC)OC)(=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.