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What are Biosimilar Antibodies?
Biosimilar antibodies are research-grade recombinant antibodies designed to closely resemble approved therapeutic antibodies in terms of amino acid sequence, structural characteristics, and…
Read article: What are Biosimilar Antibodies?
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AMG-305
Cat. No.
AT0404
AMG 305 represents an innovative dual-targeting BiTE (bispecific T-cell engager) molecule, specifically engineered with a half-life extended (HLE) format. This molecule uniquely targets both P-cadherin (CDH3) and mesothelin (MSLN) on tumor cells, in addition to CD3 on T-cells. The design of AMG 305 aims to enhance the therapeutic index in solid tumors by selectively engaging T-cells to tumor cells that co-express CDH3 and MSLN, while minimizing interaction with normal cells that express only one of these antigens. This selective mechanism of action positions AMG 305 as a promising candidate for targeted cancer therapy, especially in settings where both CDH3 and MSLN are overexpressed.
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Product Details
| Manufacturer | Adooq Bioscience |
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Storage
Store lyophilized at -20°C, keep desiccated.
In lyophilized form, the antibody is stable for 36 months.
After reconstitution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.