Other Targets

Cat. No.

A41748

CAS No.

2938864-88-9

Tizetatug rezetecan

Synonyms: SHR-A1921

Tizetatug rezetecan is an antibody-drug conjugate (ADC) designed to target and inhibit cancer cell proliferation. Comprising the antibody Tizetatug and the cytotoxic component MC-Gly-Gly-Phe-Gly-(R)-Cyclopropane-Exatecan, this compound exhibits potent anticancer activity. It is primarily utilized for research applications focused on the treatment of various cancer types, particularly in studies evaluating targeted therapy efficacy and drug resistance mechanisms.

Cat. No.

A57279

CAS No.

3051777-50-2

Amesotatug

Amesotatug is a humanized monoclonal antibody targeting annexin A1 (ANXA1). This antibody demonstrates significant antineoplastic activity by binding to human ANXA1, making it a valuable tool in cancer research. Its ability to interact with ANXA1 highlights its potential application in studies focused on tumor biology and therapeutic strategies in oncology.

Cat. No.

A64235

CAS No.

3058391-51-5

Lexucitug

Lexucitug is a humanized monoclonal antibody that specifically inhibits CD93. As a human IgG1κ isotype, it serves as a precise tool for studying CD93's role in various biological processes. This antibody is essential for research applications focusing on immunology and cellular interactions in disease models.

Cat. No.

A64652

CAS No.

2911556-99-3

Nebaprubart

Synonyms: JJP-1212

Nebaprubart is a humanized IgG4κ antibody that specifically targets the Fc receptor for IgA (FCAR/CD89). This antibody plays a critical role in modulating immune responses and is valuable for research applications involving immune cell signaling, antibody interactions, and the study of immune-mediated diseases. Its specificity for FCAR/CD89 makes it an essential tool for investigating the functions and regulatory mechanisms of IgA in various biological contexts.

Cat. No.

AT0009

Anti-BST2/CD317 Antibody

This monoclonal antibody specifically targets bone marrow stromal antigen 2 (BST2), also known as CD317 or tetherin, a protein involved in antiviral defense and immune regulation. BST2 is upregulated in various cancers and viral infections, making this antibody a useful tool for investigating tumor immunology, viral budding mechanisms, and innate immune signaling.

Cat. No.

AT0013

Anti-Sphingosine-1-phosphate Antibody

Cat. No.

AT0033

CAS No.

595566-61-3

Pagibaximab

Synonyms: BSYX-A 110; Anti-S. Epidermidis LTA Recombinant Antibody

Pagibaximab is a chimeric IgG1 monoclonal antibody directed against lipoteichoic acid (LTA), a surface component of Staphylococcus aureus and Staphylococcus epidermidis. It is primarily used in research related to neonatal sepsis and staphylococcal infections, with applications in pathogen-specific immune response and anti-bacterial antibody therapy.

Cat. No.

AT0037

CAS No.

527698-09-5

Balugrastim

Synonyms: CG 10639

Balugrastim is a long-acting recombinant granulocyte colony-stimulating factor (G-CSF) generated through genetic fusion with human serum albumin. Designed to prolong serum half-life, Balugrastim promotes neutrophil production and is used in preclinical models of chemotherapy-induced neutropenia and breast cancer–associated myelosuppression.

Cat. No.

AT0038

CAS No.

2407378-48-5

Litifilimab

Synonyms: BIIB059

Litifilimab is a humanized IgG1κ monoclonal antibody targeting CLEC4C (blood dendritic cell antigen 2, BDCA2), a receptor selectively expressed on plasmacytoid dendritic cells. Litifilimab is used in the study of autoimmune skin disorders, including cutaneous lupus erythematosus (CLE), for its role in modulating type I interferon production.

Cat. No.

AT0044

Anti-Histone H4 Antibody

Cat. No.

AT0053

Anti-GPR73/PROKR1 Antibody

The Anti-GPR73/PROKR1 Antibody is a recombinantly produced human monoclonal antibody, expressed in Chinese Hamster Ovary (CHO) cells. It specifically targets the GPR73/PROKR1 receptor, which is implicated in various physiological processes. This antibody is composed of a human IgG4SP heavy chain and a human kappa light chain, and exhibits a molecular weight of approximately 150 kDa. For experimental control purposes, the recommended isotype control is Human IgG1 kappa.

Cat. No.

AT0063

Anti-DCBLD2/ESDN Antibody (FA19-1)

Synonyms: FA19-1

The Anti-DCBLD2/ESDN Antibody (FA19-1) is a humanized monoclonal antibody, produced in Chinese Hamster Ovary (CHO) cells, specifically designed to target DCBLD2/ESDN. This antibody is comprised of a human IgG1 heavy chain and a human kappa light chain, culminating in a molecular weight of approximately 150 kDa. For experimental control purposes, the Human IgG1 kappa Isotype Control is recommended as an appropriate reference standard. This product is essential for researchers focusing on cellular signaling, vascular biology, and cancer research, providing a critical tool for elucidating the role of DCBLD2/ESDN in various biological processes.

Cat. No.

AT0082

CAS No.

1384099-30-2

Eflapegrastim

Eflapegrastim, a human IgG4 monoclonal antibody, functions as a granulocyte colony-stimulating factor (G-CSF). This biologic specifically binds to the G-CSF receptor (c-Fms), playing a crucial role in the hematopoietic system. It effectively stimulates the proliferation and differentiation of neutrophil progenitor cells, ensuring the maintenance of adequate levels of mature and functional neutrophils. Additionally, Eflapegrastim is instrumental in reducing the duration of neutropenia, thereby enhancing patient recovery and resilience in clinical settings. This makes it an essential therapeutic agent in managing conditions associated with reduced neutrophil counts, such as those experienced during chemotherapy.

Cat. No.

AT0108

Anti-Bcl-2 Antibody

The Anti-Bcl-2 Antibody is a humanized monoclonal antibody produced in Chinese Hamster Ovary (CHO) cells, specifically designed to target B-cell lymphoma 2 (Bcl-2). This antibody is comprised of a human IgG1 heavy chain and a human kappa light chain, with a predicted molecular weight of 145.74 kDa. For experimental control purposes, the recommended isotype control is Human IgG1 kappa. This antibody is essential for research focused on apoptosis and cancer biology, particularly in studies investigating the regulation of cell death and survival.

Cat. No.

AT0113

CAS No.

658052-09-6

Mapatumumab

Synonyms: HGS-ETR1; Anti-Human TNFRSF10A Recombinant Antibody

Mapatumumab (HGS-ETR1) is a fully human IgG1 monoclonal antibody designed as an agonist for tumor necrosis factor-related apoptosis-inducing ligand receptor 1 (TRAIL-R1). This antibody selectively binds to TRAIL-R1, potentially inducing apoptosis in cells expressing this receptor. Mapatumumab is primarily utilized in oncological research to study its efficacy and mechanism in promoting cancer cell apoptosis.

Cat. No.

AT0123

CAS No.

2414962-49-3

Sirexatamab

Sirexatamab is a biologically active peptide designed for use in a variety of biochemical studies. This peptide specifically targets and binds to its corresponding receptor, making it an ideal candidate for research focused on receptor-ligand interactions, signaling pathways, and cellular responses. Sirexatamab's high specificity and efficacy are essential for researchers studying these critical aspects of cell biology and molecular medicine.

Cat. No.

AT0131

CAS No.

1644134-10-0

Tabituximab

Synonyms: ONC-005; OTSA101

Tabituximab (OTSA101) is a humanized monoclonal antibody designed to specifically target the frizzled class receptor 10 (FZD10). This antibody binds with high specificity to FZD10, a receptor implicated in several oncogenic processes, making it a critical component in cancer research and therapeutic development.

Cat. No.

AT0142

CAS No.

1463459-96-2

Ascrinvacumab

Synonyms: Anti-ACVRL1 / ALK-1 Reference Antibody (ascrinvacumab; PF-03446962

Ascrinvacumab (PF-03446962) is a human IgG2 monoclonal antibody that specifically targets activin receptor-like kinase 1 (ALK-1). Demonstrating a high binding affinity, Ascrinvacumab interacts with human ALK1 with a dissociation constant (Kd) of 7 nM. This antibody is primarily utilized in scientific studies focused on the pathogenesis and therapeutic interventions of hepatocellular carcinoma (HCC).

Cat. No.

AT0148

Anti-SLC40A1 Antibody

The Anti-SLC40A1 Antibody is a human-derived monoclonal antibody produced in Chinese Hamster Ovary (CHO) cells. It specifically targets the SLC40A1 protein, with a predicted molecular weight of 150 kDa. This antibody is designed for the precise detection and study of SLC40A1, a key transporter involved in iron homeostasis and related biological processes.

Cat. No.

AT0158

CAS No.

2767983-94-6

Ibentatug

Ibentatug is a human IgG1 κ monoclonal antibody targeting CSP1. For experimental rigor and control, it is recommended to use Human IgG1 kappa Isotype Control.

Cat. No.

AT0167

CAS No.

1345009-45-1

Vantictumab

Synonyms: OMP-18R5

Vantictumab (OMP-18R5) is a fully human IgG2 monoclonal antibody designed to inhibit Wnt pathway signaling. This inhibition is achieved through its specific binding to Frizzled receptors FZD1, FZD2, FZD5, FZD7, and FZD8. The antibody's mechanism of action includes direct effects on tumor cells, including cancer stem cells (CSCs), as well as modulatory effects on the tumor stroma. Vantictumab is primarily researched for its potential therapeutic applications in treating conditions such as metastatic HER2-negative breast cancer and metastatic pancreatic adenocarcinoma.

Cat. No.

AT0178

BHQ-880

BHQ-880 is a humanized monoclonal antibody produced in Chinese Hamster Ovary (CHO) cells, specifically designed to target Dickkopf-related protein 1 (DKK1). This antibody has a predicted molecular weight of 142.96 kDa. For isotype control purposes, Human IgG1 kappa, Isotype Control is recommended. BHQ-880 is utilized primarily in research focused on understanding and modulating Wnt signaling pathways implicated in various diseases, including cancer and osteoporosis.

Cat. No.

AT0183

Anti-CLEC4C Antibody

The Anti-CLEC4C Antibody is a humanized monoclonal antibody produced in Chinese Hamster Ovary (CHO) cells, specifically designed to target CLEC4C. This antibody is composed of a human IgG1 type heavy chain and a human lambda (λ) type light chain. It has a predicted molecular weight of 150 kDa, making it suitable for a variety of biochemical and immunological applications, including flow cytometry, western blotting, and immunohistochemistry. This specificity and configuration ensure high affinity and selectivity towards CLEC4C, a key marker in dendritic cell biology and immune response studies.

Cat. No.

AT0188

Anti-TMPRSS2 Antibody

The Anti-TMPRSS2 Antibody is a humanized monoclonal antibody produced in Chinese Hamster Ovary (CHO) cells, specifically designed to target the TMPRSS2 enzyme. This antibody is composed of a human IgG1 heavy chain and a human kappa light chain, with a molecular weight of approximately 150 kDa. For appropriate isotype controls, researchers should use the Human IgG1 kappa, Isotype Control. This product is ideal for studies focusing on the role of TMPRSS2 in disease processes, particularly in the context of viral entry and pathogenesis.

Cat. No.

AT0189

CAS No.

331243-22-2

Pascolizumab

Synonyms: SB-240683

Pascolizumab (SB-240683) is a humanized monoclonal antibody that targets interleukin-4 (IL-4), a key cytokine involved in inflammatory and allergic responses. This antibody is specifically designed for the investigation of its therapeutic potential in asthma research, offering a promising tool for elucidating the role of IL-4 in asthma pathogenesis and for exploring novel treatment strategies.