Fig. 1 · Structure
Documents & Downloads
AMG 7905
Cat. No.
A68778
CAS
1026876-55-0
TRPV1 Antagonist
AMG 7905 is a selective antagonist of the transient receptor potential vanilloid type 1 (TRPV1), known for its role in mediating pain and thermoregulation. This compound effectively inhibits TRPV1 channel activation by capsaicin while enhancing channel activation by protons. AMG 7905 is employed in research focusing on pain modulation, thermogenesis inhibition, and the physiological responses to temperature changes.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 1026876-55-0 |
| Applications | TRPV1 Antagonist |
| Formula | C25H24F3N5S |
| Molecular Weight | 483.55 |
| SMILES | FC(F)(C1=CC(NCC2CCCCC2)=C(C3=CC(NC4=CC5=C(N=CS5)C=C4)=NC=N3)C=C1)F |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.