Fig. 1 · Structure
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AMG 9090
Cat. No.
A68805
CAS
118215-82-0
TRP Channel Agonist
AMG 9090 is a partial agonist of the rat TRPA1 channel, exhibiting significant pharmacological activity in models of pain and inflammation. TRPA1 plays a critical role in detecting reactive compounds that induce pain responses in both humans and rodents. Notably, AMG 9090 demonstrates a distinct antagonistic effect on human TRPA1 activated by AITC and noxious cold, while functioning as a partial agonist in rat TRPA1. This profile highlights the compound’s potential utility as a therapeutic agent targeting TRPA1-mediated pain and inflammation, with additional inhibitory effects observed on TRPM8 channels.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Partial Agonist |
| CAS Number | 118215-82-0 |
| Applications | TRP Channel Agonist |
| Formula | C15H11Cl4NOS |
| Molecular Weight | 395.13 |
| SMILES | ClC(Cl)(Cl)C(SC1=CC=C(Cl)C=C1)NC(C2=CC=CC=C2)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.