Fig. 1 · Structure
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AMG8788
Cat. No.
A68841
CAS
1159996-43-6
TRPM8 Antagonist
AMG8788 is a selective, orally active antagonist of the transient receptor potential melastatin 8 (TRPM8), exhibiting an IC50 of 63.2 nM. This compound demonstrates significant inhibitory activity on TRPM8, making it valuable for studying sensory perception, pain pathways, and thermoregulation. It serves as an important tool for research into conditions associated with TRPM8 modulation, including neuropathic pain and cold sensitivity.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 1159996-43-6 |
| Applications | TRPM8 Antagonist |
| Formula | C23H18F4N2O |
| Molecular Weight | 414.40 |
| SMILES | O=C(N1CCC2=C(C=CC=C2)[C@H]1C3=CC=C(C(F)(F)F)C=C3)NC4=CC=C(F)C=C4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.