Fig. 1 · Structure
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AMG9678
Cat. No.
A68844
CAS
1159997-27-9
TRPM8 Antagonist
AMG9678 is a selective, orally active antagonist of the transient receptor potential melastatin 8 (TRPM8) channel, exhibiting a potent inhibitory effect with an IC50 value of 31.2 nM. This compound is utilized in research focused on pain modulation, thermosensation, and neurogenic inflammation, providing insights into the role of TRPM8 in various physiological and pathological processes. Its specificity and potency make it a valuable tool for investigating TRPM8-related biological pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 1159997-27-9 |
| Applications | TRPM8 Antagonist |
| Formula | C20H18F6N2O |
| Molecular Weight | 416.36 |
| SMILES | O=C(N1CCC2=C(C=CC=C2)[C@H]1C3=CC=C(C(F)(F)F)C=C3)N[C@@H](C)C(F)(F)F |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.