Fig. 1 · Structure
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Anagyrine
nAChR Desensitizer
Anagyrine is a quinolizidine alkaloid that acts as a desensitizer of nicotinic acetylcholine receptors (nAChR). It demonstrates binding affinity with IC50 values of 132 µM for muscarinic receptors and 2096 µM for nicotinic receptors, effectively modulating nAChR activity. This compound is utilized in research to study nAChR desensitization mechanisms and its implications in various neural and pharmacological contexts.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 486-89-5 |
| Applications | nAChR Desensitizer |
| Formula | C15H20N2O |
| Molecular Weight | 244.33 |
| Synonyms | (-)-Anagyrine; Monolupine; Rhombinine |
| SMILES | O=C1N2C([C@]3([H])C[C@]([C@]4([H])N(CCCC4)C3)([H])C2)=CC=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.