Fig. 1 · Structure
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Anatibant
Bradykinin B2 Receptor Antagonist
Anatibant is a selective non-peptide antagonist of the bradykinin B2 receptor. It demonstrates high affinity for recombinant human, rat, and guinea-pig B2 receptors, with Ki values of 0.67 nM, 1.74 nM, and 1.37 nM, respectively. This compound effectively crosses the blood-brain barrier, making it a valuable tool for investigating the role of bradykinin signaling in brain damage diseases and related neuroinflammatory conditions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 209733-45-9 |
| Applications | Bradykinin B2 Receptor Antagonist |
| Formula | C34H36Cl2N6O5S |
| Molecular Weight | 711.66 |
| Synonyms | LF 16-0687; XY-2405 |
| SMILES | O=C(NCCCNC(C1=CC=C(C=C1)C(N)=N)=O)[C@H]2N(CCC2)S(=O)(C3=CC=C(C(COC4=C5N=C(C=C(C5=CC=C4)C)C)=C3Cl)Cl)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.