Fig. 1 · Structure
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Annonacin
Mitochondrial Complex I Inhibitor
Annonacin is a potent inhibitor of mitochondrial Complex I, disrupting the electron transport chain and leading to decreased ATP production. This compound has demonstrated significant cytotoxic effects against various cancer cell lines, including ovarian, cervical, breast, bladder, and skin cancers, by inducing apoptosis through Bax and Caspase-3 pathways. Additionally, Annonacin affects sodium/potassium and sarcoplasmic reticulum ATPase pumps, contributing to its overall biological activity. It serves as a valuable tool for research into cancer therapy and mitochondrial dysfunction.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 111035-65-5 |
| Applications | Mitochondrial Complex I Inhibitor |
| Formula | C35H64O7 |
| Molecular Weight | 596.88 |
| SMILES | O=C1O[C@@H](C)C=C1C[C@H](O)CCCCC[C@@H](O)CCCC[C@@H](O)[C@@H]2O[C@@H]([C@H](O)CCCCCCCCCCCC)CC2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.