Antalarmin hydrochloride is an orally active, non-peptide antagonist of corticotropin-releasing hormone receptor 1 (CRHR1) with a Ki of 1 nM. It effectively suppresses CRH-induced adrenocorticotropic hormone (ACTH) secretion and blocks both CRH- and novelty-induced anxiety-like behaviors in animal models. Antalarmin hydrochloride also exhibits anti-inflammatory activity in arthritis models and alleviates stress-induced gastric ulceration, supporting its potential in research related to irritable bowel syndrome and stress-related inflammatory conditions.
Antalarmin hydrochloride is an orally active, non-peptide antagonist of corticotropin-releasing hormone receptor 1 (CRHR1) with a Ki of 1 nM. It effectively suppresses CRH-induced adrenocorticotropic hormone (ACTH) secretion and blocks both CRH- and novelty-induced anxiety-like behaviors in animal models. Antalarmin hydrochloride also exhibits anti-inflammatory activity in arthritis models and alleviates stress-induced gastric ulceration, supporting its potential in research related to irritable bowel syndrome and stress-related inflammatory conditions.
Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
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