Fig. 1 · Structure
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Antibacterial agent 236
DNA Gyrase Inhibitor
Antibacterial agent 236 is a potent inhibitor of DNA gyrase and topoisomerase IV, with IC50 values of 3.2 nM and 300 nM against Staphylococcus aureus, respectively. This compound demonstrates broad-spectrum antibacterial activity and possesses favorable pharmacokinetic properties in murine models. It is applicable in research focused on bacterial infections and the mechanism of action of DNA replication inhibitors.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2364479-10-5 |
| Applications | DNA Gyrase Inhibitor |
| Formula | C26H27N5O2S |
| Molecular Weight | 473.59 |
| SMILES | O=C1NC2=CC(CNC3CCN(CC3)CCN(C4=C(C=C5)C=CC(C#N)=C4)C5=O)=CC=C2SC1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.