Fig. 1 · Structure
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Anticancer agent 143
Dual PTPN2/PTP1B Inhibitor
Anticancer agent 143 is a dual inhibitor of PTPN2 and PTP1B, demonstrating potent bioactivity with IC50 values of less than 2.5 nM. This compound is valuable for cancer research, providing insights into the roles of these protein tyrosine phosphatases in tumor biology and potential therapeutic strategies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2948339-38-4 |
| Applications | Dual PTPN2/PTP1B Inhibitor |
| Formula | C19H15BrF2N3O6PS2 |
| Molecular Weight | 594.34 |
| SMILES | O=P(O)(C(F)(C1=C(Br)C2=C(C(OCC3=CC=C(S(=O)(C)=O)C=C3)=CC(C4=CN=NN4)=C2)S1)F)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.