- Cat. No.
- A20594
SHP099
SHP099 is a potent, selective, orally available SHP2 inhibitor with an IC50 of 70 nM.
-
-
- Cat. No.
- A14063
Suramin sodium salt
Synonyms: Suramin hexasodium salt
Suramin sodium salt acts as a reversible and competitive inhibitor of protein-tyrosine phosphatases (PTPases). It demonstrates potent inhibitory activity against sirtuins, specifically SirT1 (IC50=297 nM), SirT2 (IC50=1.15 μM), and SirT5 (IC50=22 μM). Additionally, Suramin sodium salt inhibits reverse transcriptase and shows strong efficacy as a SARS-CoV-2 RNA-dependent RNA polymerase inhibitor. Its diverse biochemical properties make it a valuable tool for research in antiparasitic, anti-neoplastic, and anti-angiogenic studies.
In stock View Details -
- Cat. No.
- A14770
Bakuchiol
Synonyms: (S)-(+)-Bakuchiol; (S)-Bakuchiol; Drupanol; UP 256
Bakuchiol is an antioxidant inhibitor of protein tyrosine phosphatase 1B (PTP1B).
In stock View Details -
- Cat. No.
- A15382
Alexidine dihydrochloride
Alexidine is an alkyl bis(biguanide) antiseptic which has been used in mouthwashes to eliminate plaque forming microorganisms.
In stock View Details -
- Cat. No.
- A15383
BVT 948
BVT 948 is a non-competitive PTP (protein tyrosine phosphatase) inhibitor.
In stock View Details -
- Cat. No.
- A15384
NSC 87877
NSC 87877 is a potent inhibitor of shp2 and shp1 protein tyrosine phosphatases (SH-PTP2 and SH-PTP1).
In stock View Details -
- Cat. No.
- A15390
TCS 401 free base
Synonyms: TCS401
TCS 401 is a selective inhibitor of protein-tyrosine phosphatase 1B (PTP1B) (Ki values are 0.29, 59, 560, 1100, > 2000, > 2000 and > 2000 μM for PTP1B, CD45 D1D2, PTPβ, PTPε D1, SHP-1, PTPα D1 and LAR D1D2 respectively).
In stock View Details -
- Cat. No.
- A16120
NSC87877 disodium
NSC-87877 is a cell-permeable inhibitor of both SHP-1 and SHP-2 with IC50 values of 355 and 318 nM respectively.
In stock View Details -
- Cat. No.
- A18008
Sodium stibogluconate
Synonyms: Stibogluconate trisodium nonahydrate
Sodium stibogluconate (Stibogluconate trisodium nonahydrate) is a potent inhibitor of protein tyrosine phosphatase. Sodium stibogluconate inhibits 99% of SHP-1, SHP-2 and PTP1B activity at 10, 100, 100 μg/mL, respectively.
In stock View Details -
- Cat. No.
- A18613
SHP394
SHP394 is an orally efficacious protein tyrosine phosphatase SHP2 inhibitor with an IC50 of 23 nM.
In stock View Details -
- Cat. No.
- A18674
DPM-1001
DPM-1001 is a potent, specific, orally bioavailable and non-competitive inhibitor of protein-tyrosine phosphatase (PTP1B) with an IC50 of 100 nM, an an analog of the specific PTP1B inhibitor trodusquemine (MSI-1436; IC50=600 nM). DPM-1001 has anti-diabetic property.
In stock View Details -
- Cat. No.
- A18893
RMC-4550
RMC-4550 is a potent, selective and allosteric inhibitor of SHP2, with an IC50 of 0.583 nM.
In stock View Details -
- Cat. No.
- A18934
7-BIA
7-BIA is a receptor-type protein tyrosine phosphatase D (PTPRD) inhibitor with an IC50 of ~1-3 μM.
In stock View Details -
- Cat. No.
- A19099
SHP2 IN-1
SHP2 IN-1 (compound 13) is an allergic inhibitor of SHP2 (PTPN11), with an IC50 of 3 nM.
In stock View Details -
- Cat. No.
- A19109
PTP1B-IN-8
PTP1B-IN-8 is a potent and selective potent protein tyrosine phosphatase-1B (PTP1B) inhibitor extracted from patent CN103626692A, example 1.
In stock View Details -
- Cat. No.
- A19276
cyt-PTPε Inhibitor-1
cyt-PTPε Inhibitor-1 is a potent cytosolic protein tyrosine phosphatase epsilon (cyt-PTPε) inhibitor, binds to the catalytic domain of cyt-PTPε, blocks c-Src activation (dephosphorylation of c-Src), and exhibits anti-osteoclastic activity.
In stock View Details -
- Cat. No.
- A20423
TPI-1
TPI-1, also known as Tyrosine Phosphatase Inhibitor 1, is a SHP-1 inhibitor; inhibits recombinant SHP-1 with an IC50 of 40 nM.
In stock View Details -
- Cat. No.
- A20428
PTP1B-IN-2
PTP1B-IN-2 is a potent protein tyrosine phosphatase 1B (PTP1B) inhibitor with an IC50 of 50 nM.
In stock View Details -
- Cat. No.
- A20776
JTT 551
JTT 551 is selective a protein tyrosine phosphatase 1B (PTP1B) inhibitor, with Kis of 0.22 μM and 9.3 μM for PTP1B and TCPTP (T-cell protein tyrosine phosphatase), respectively; JTT 551 can be used in the research of type 2 diabetes mellitus.
In stock View Details -
- Cat. No.
- A20815
Ertiprotafib
Synonyms: PTP 112
Ertiprotafib is an inhibitor of PTP1B, IkB kinase β (IKK-β), and a dual PPARα and PPARβ agonist, with an IC50 of 1.6 μM for PTP1B, 400 nM for IKK-β, an EC50 of ~1 μM for PPARα/PPARβ.
In stock View Details -
- Cat. No.
- A21149
PTP1B-IN-3
PTP1B-IN-3 is a potent and selective PTP1B inhibitor with IC50s of 120 nM (PTP1B) and 120 nM (TCPTP), respectively.
In stock View Details -
- Cat. No.
- A21762
SHP099 hydrochloride
Synonyms: SHP-099
SHP099 hydrochloride is a potent, selective and orally available SHP2 inhibitor with an IC50 of 70 nM.
In stock View Details -
- Cat. No.
- A21859
TCS 401
TCS 401 is a selective inhibitor of protein tyrosine phosphatase 1B (PTP1B).
In stock View Details -
- Cat. No.
- A22000
PTP1B-IN-1
Synonyms: PTP1B inhibitor
PTP1B-IN-1 is a potent protein tyrosine phosphatase-1B (PTP1B) inhibitor with IC50 of 1.6 mM; 1,2,5-thiadiazolidin-3-one-1,1-dioxide scaffold for derivatives synthesis.
In stock View Details -
- Cat. No.
- A22159
IACS-13909
IACS-13909 is a selective, potent and orally active SHP2 allosteric inhibitor with an IC50 of 15.7 nM and a Kd of 32 nM.
In stock View Details