Anticancer agent 199 is an apoptosis and ferroptosis inducer targeting multiple signaling pathways in triple negative breast cancer (TNBC) cells. It promotes cell death through the mitochondrial pathway by inhibiting EGFR, AKT, and MAPK signaling, while simultaneously down-regulating LCN2 to induce ferroptosis. This compound effectively reduces TNBC cell viability and migration, and induces S phase cell cycle arrest, making it a valuable tool for research on cancer therapeutics. Anticancer agent 199 is a derivative of the cyclin-dependent kinase inhibitor Rocovitine.
Anticancer agent 199 is an apoptosis and ferroptosis inducer targeting multiple signaling pathways in triple negative breast cancer (TNBC) cells. It promotes cell death through the mitochondrial pathway by inhibiting EGFR, AKT, and MAPK signaling, while simultaneously down-regulating LCN2 to induce ferroptosis. This compound effectively reduces TNBC cell viability and migration, and induces S phase cell cycle arrest, making it a valuable tool for research on cancer therapeutics. Anticancer agent 199 is a derivative of the cyclin-dependent kinase inhibitor Rocovitine.
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