Fig. 1 · Structure
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Antimalarial agent 10
Antimalarial Agent
Antimalarial Agent 10 (Compound 17b) is an aminoalcohol quinoline compound that targets the Plasmodium falciparum species associated with malaria. It exhibits potent antimalarial activity, with IC50 values of 14.9 nM against Pf3D7 and 11.0 nM against PfW2, demonstrating its efficacy in inhibiting parasite growth. Additionally, it displays a selectivity index exceeding 770, indicating minimal toxicity to host cell lines. This compound is suitable for research applications focused on malaria treatment and development of antimalarial therapies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 2747280-03-9 |
| Applications | Antimalarial Agent |
| Formula | C23H22F6N2O2 |
| Molecular Weight | 472.42 |
| SMILES | FC(F)(C1=CC=CC2=C1N=C(C(F)(F)F)C=C2[C@H](O)CN[C@H](COC)CC3=CC=CC=C3)F |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.