Fig. 1 · Structure
Documents & Downloads
Antimalarial agent 11
Antimalarial Agent
Antimalarial Agent 11, a spirocyclic chromane, acts as a potent inhibitor of malaria parasites. It demonstrates significant antimalarial activity, with an EC50 of 350 nM against the Chloroquine-resistant Dd2 strain, and EC50 values of 1.48 µM and 1.81 µM against the D6 and ARC08-022 strains, respectively. This compound is useful for research focusing on drug resistance and the development of new therapeutics in malaria treatment.
In Stock
Free Aliquoting for Your Order
Tell us your preferred amount per vial. We’ll confirm the options.
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1214454-56-4 |
| Applications | Antimalarial Agent |
| Formula | C25H25F2NO3 |
| Molecular Weight | 425.47 |
| SMILES | OC(CN1CCC2(CC(O)C3=C(O2)C4=C(C=CC=C4)C=C3)CC1)C5=CC=C(F)C(F)=C5 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.