Fig. 1 · Structure
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Antimalarial agent 38
Antimalarial Agent
Antimalarial agent 38 is an orally active compound that targets Plasmodium falciparum, demonstrating effective inhibition of both Chloroquine-sensitive and Chloroquine-resistant strains, with IC50 values of 0.5 μM for the D6 strain, 13 μM for the Thai strain, 1 μM for the FcB1 strain, and 13 μM for the K1 strain. This agent exhibits non-cytotoxicity in mammalian MCR58 cells (IC50 > 140 μM). Additionally, antimalarial agent 38 has been shown to enhance the survival rate in a mouse model infected with Plasmodium yoelii nigeriensis, making it a valuable tool for antimalarial research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 123580-46-1 |
| Applications | Antimalarial Agent |
| Formula | C36H40N2O12 |
| Molecular Weight | 692.71 |
| SMILES | O=C(COC1=C(OC)C=CC(C(OC2=C3C(O)=CC(OCC(N4CCN(CC4)CC5=CC=C(C(OC)=C5OC)OC)=O)=C2)=CC3=O)=C1)OCC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.