Fig. 1 · Structure
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Antitumor agent-138
Antitumor Agent
Antitumor agent-138 is a potent inhibitor of tubulin polymerization that acts on the colchicine-binding sites of tubulin, exhibiting an IC50 of 1.87 μM. It effectively arrests the cell cycle at the G2/M phase and induces apoptosis in MCF-7 breast cancer cells. Additionally, Antitumor agent-138 demonstrates inhibitory effects on cell migration and angiogenesis, making it a valuable tool in cancer research applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2975168-22-8 |
| Applications | Antitumor Agent |
| Formula | C20H21N3O4 |
| Molecular Weight | 367.40 |
| SMILES | CC1=CC=C(C2=CC(N)=NN2C(C3=CC(OC)=C(OC)C(OC)=C3)=O)C=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.