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Ap5dT

Catalog No.: A55858
Cytosolic Thymidine Kinase/Mitochondrial Enzyme Inhibitor
Ap5dT is an inhibitor of cytosolic thymidine kinase and mitochondrial enzymes, exhibiting inhibition constants (Kis) of 0.12 μM and 0.50 μM, respectively. This compound is relevant for research on acute myelocytic leukemia, facilitating investigations into thymidine metabolism and its implications in cancer biology. Its selective inhibition properties make Ap5dT a valuable tool for studying metabolic pathways involved in cellular proliferation.
Ap5dT 103137-88-8 Cytosolic Thymidine Kinase/Mitochondrial Enzyme Inhibitor
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionAp5dT is an inhibitor of cytosolic thymidine kinase and mitochondrial enzymes, exhibiting inhibition constants (Kis) of 0.12 μM and 0.50 μM, respectively. This compound is relevant for research on acute myelocytic leukemia, facilitating investigations into thymidine metabolism and its implications in cancer biology. Its selective inhibition properties make Ap5dT a valuable tool for studying metabolic pathways involved in cellular proliferation.
Product Information
Catalog NumA55858
FormulaC20H30N7O23P5
Molecular Weight891.35
CAS Number103137-88-8
SMILESO[C@@H]1[C@H](O)[C@@H](COP(OP(OP(OP(OP(OC[C@@H](O2)[C@@H](O)C[C@@H]2N3C(NC(C(C)=C3)=O)=O)(O)=O)(O)=O)(O)=O)(O)=O)(O)=O)O[C@H]1N4C5=NC=NC(N)=C5N=C4
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This equation is commonly abbreviated as: C1V1 = C2V2

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DNA Damage > Nucleoside Antimetabolite/Analog