Fig. 1 · Structure
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APJ receptor agonist 1
APJ Receptor Agonist
APJ Receptor Agonist 1 is a biphenyl acid derivative that functions as a potent agonist for the APJ receptor, exhibiting EC50 values of 0.093 nM for human and 0.12 nM for rat APJ receptors. It demonstrates significant in vitro potency comparable to that of apelin-13, the physiological ligand for the APJ receptor. This compound is valuable for research investigating heart failure and associated cardiovascular disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 2287153-38-0 |
| Applications | APJ Receptor Agonist |
| Formula | C31H26ClN3O3 |
| Molecular Weight | 524.01 |
| SMILES | O=C(C1=CC(C(N[C@@H](C2=CC=CC=C2)CCC)=O)=CC=[C@]1[C@]3=C(Cl)C=CC=C3C4=NC5=CC=CC=C5N4)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.