Fig. 1 · Structure
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APJ receptor agonist 5
APJ Receptor Agonist
APJ Receptor Agonist 5 is a potent and orally active agonist of the apelin receptor (APJ), exhibiting an EC50 of 0.4 nM. This compound demonstrates favorable pharmacokinetic properties in rodent models of heart failure, contributing to enhanced cardiac function. Additionally, APJ Receptor Agonist 5 has shown an acceptable safety profile in preclinical toxicology studies, making it a valuable tool for investigating heart failure disease mechanisms and potential therapeutic approaches.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 2135514-20-2 |
| Applications | APJ Receptor Agonist |
| Formula | C26H29N3O6 |
| Molecular Weight | 479.52 |
| SMILES | CCOCC(N(C1=C(C=CC=C1OC)OC)C(O)=C2C(N3C[C@](C4=CC=CC=C4)([H])CC3)=O)=NC2=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.