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Glutathione Peroxidase

Glutathione peroxidase (GPX) inhibitors and degraders act on selenoenzymes that reduce peroxides. These enzymes use glutathione as the electron donor for peroxide reduction. In 1973 two groups showed that glutathione peroxidase contains selenium, which linked the trace element to antioxidant defense. GPX4 reduces phospholipid hydroperoxides in membranes, and a 2014 study identified it as a central regulator of ferroptotic cell death. ML162 and ML-210 inhibit GPX4, and ML-210 was characterized in 2020 as a masked nitrile oxide that forms a covalent adduct after conversion in cells. NC-R17 and PROTAC GPX4 degrader-1 instead remove the protein by targeted degradation. The list also holds myeloperoxidase inhibitors such as verdiperstat, which act on a different peroxidase.

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  • Solasonine
    Cat. No.
    A24555
    CAS No.
    19121-58-5

    Solasonine

    Solasonine is a naturally occurring steroidal glycoalkaloid isolated from *Solanum melongena* (eggplant), known for its anti-infective, anticancer, and neurogenesis-promoting properties. It acts as a ferroptosis inducer by disrupting the glutathione redox system through inhibition of glutathione peroxidase 4 (GPX4). By promoting ferroptotic cell death in hepatocellular carcinoma (HCC) cells, Solasonine serves as a valuable compound for investigating ferroptosis mechanisms and developing novel anticancer strategies.

    In stock View Details
    1 mg
    $36.00
    5 mg
    $108.00
    All 4 sizes

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