We use analytics and advertising cookies, which you can accept or reject; see our privacy policy.

Current choice:

Glutathione Peroxidase

Glutathione peroxidase (GPX) inhibitors and degraders act on selenoenzymes that reduce peroxides. These enzymes use glutathione as the electron donor for peroxide reduction. In 1973 two groups showed that glutathione peroxidase contains selenium, which linked the trace element to antioxidant defense. GPX4 reduces phospholipid hydroperoxides in membranes, and a 2014 study identified it as a central regulator of ferroptotic cell death. ML162 and ML-210 inhibit GPX4, and ML-210 was characterized in 2020 as a masked nitrile oxide that forms a covalent adduct after conversion in cells. NC-R17 and PROTAC GPX4 degrader-1 instead remove the protein by targeted degradation. The list also holds myeloperoxidase inhibitors such as verdiperstat, which act on a different peroxidase.

2 Items

  • GPX4 activator 1
    Cat. No.
    A26982
    CAS No.
    1030098-18-0

    GPX4 activator 1

    GPX4 Activator 1 is an allosteric modulator that targets GPX4, demonstrating a Kd of 5.86 μM and an EC50 of 19.19 μM. This compound effectively enhances GPX4 activity, thereby inhibiting ferroptosis by preventing the accumulation of intracellular lipid peroxides induced by ferroptosis inducers. It serves as a valuable tool for researchers studying ferroptosis mechanisms and potential therapeutic interventions in diseases associated with oxidative stress.

    In stock View Details
    5 mg
    $125.00
    10 mg
    $195.00
    All 5 sizes
  • Pipecolic acid
    Cat. No.
    A27031
    CAS No.
    535-75-1

    Pipecolic acid

    Pipecolic acid is a metabolite of lysine that acts as a YAP-GPX4 signaling modulator. It exhibits antioxidant properties and has been shown to reduce retinal vascular tube formation while mitigating ferroptosis. This compound enhances voltage-sensitive Ca2+ channel currents and can induce neuronal apoptosis, making it a valuable tool for research on diabetic retinopathy. Its ability to cross the blood-brain barrier further supports its application in neurological studies.

    In stock View Details
    100 mg
    $20.00
    500 mg
    $25.00
    All 7 sizes

2 Items

Added to your cart

View Cart Checkout

    Loading...