Fig. 1 · Structure
Documents & Downloads
AQX-435
SHIP1 Activator
AQX-435 is a potent activator of SHIP1 phosphatase. This compound effectively reduces PI3K activation downstream of the B-cell receptor (BCR), leading to the induction of apoptosis in malignant B cells and demonstrating significant inhibition of lymphoma growth. It serves as a valuable tool for research into targeted therapies for B-cell malignancies.
In Stock
Free Aliquoting for Your Order
Tell us your preferred amount per vial. We’ll confirm the options.
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Activator |
| CAS Number | 1619983-52-6 |
| Applications | SHIP1 Activator |
| Formula | C27H34N2O4 |
| Molecular Weight | 450.57 |
| SMILES | O=C(C1=CC=CN=C1)N[C@@H]2C[C@@]3([H])C(C)(C)CCC[C@]3(C)[C@@H](C(C4=CC(O)=CC(O)=C4)=O)[C@@H]2C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.