Fig. 1 · Structure
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ART558
Polθ Inhibitor
ART558 is a potent and selective allosteric inhibitor of DNA polymerase theta (Polθ), exhibiting an IC50 of 7.9 nM. This compound induces synthetic lethality in BRCA-deficient cells and promotes DNA damage, making it a valuable tool for cancer research, particularly in the study of breast cancer. Its unique mechanism of action presents opportunities for investigating therapeutic strategies targeting Polθ in various malignancies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2603528-97-6 |
| Applications | Polθ Inhibitor |
| Formula | C21H21F3N4O2 |
| Molecular Weight | 418.41 |
| SMILES | CN(C1=CC(C)=CC=C1)C([C@H]2N(C3=C(C(C(F)(F)F)=CC(C)=N3)C#N)CC[C@H]2O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.