Fig. 1 · Structure

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AS2690168 hydrochloride

RANKL Inhibitor

AS2690168 hydrochloride is an orally active inhibitor of RANKL signaling, specifically targeting the receptor activator of nuclear factor kappa-Β ligand. This compound effectively suppresses RANKL-induced osteoclastogenesis in RAW264 cells, making it a valuable tool for studying mechanisms of pathological osteolysis and related bone diseases. Its application in research can provide insights into potential therapeutic strategies for conditions associated with abnormal osteoclast activity.

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Specifications

Manufacturer Adooq Bioscience
Actions Inhibitor
CAS Number 1393899-47-2
Applications RANKL Inhibitor
Formula C17H14ClF3N4O
Molecular Weight 382.77
SMILES
FC1=CC(F)=C(CNC2=NC(C3=CC=CC=N3)=NC=C2OC)C(F)=C1.Cl

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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