Aselizumab (HuDreg-55) is a humanized IgG4 monoclonal antibody targeting L-selectin (CD62L), a cell adhesion molecule predominantly expressed on circulating neutrophils. L-selectin facilitates the migration of these cells to sites of injury via chemotaxis. Due to its mechanism of action, Aselizumab has been associated with an increased incidence of infections and leukopenia following trauma. This antibody is pivotal for research into immune response modulation and the potential therapeutic management of inflammatory conditions.
Aselizumab (HuDreg-55) is a humanized IgG4 monoclonal antibody targeting L-selectin (CD62L), a cell adhesion molecule predominantly expressed on circulating neutrophils. L-selectin facilitates the migration of these cells to sites of injury via chemotaxis. Due to its mechanism of action, Aselizumab has been associated with an increased incidence of infections and leukopenia following trauma. This antibody is pivotal for research into immune response modulation and the potential therapeutic management of inflammatory conditions.
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Calculate the dilution required to prepare a stock solution.This equation is commonly abbreviated as: C1V1 = C2V2
Frequently Asked Questions
What are Biosimilar Antibodies?
Biosimilar antibodies are research-grade recombinant antibodies designed to closely resemble approved therapeutic antibodies in terms of amino acid sequence, structural characteristics, and biological activity. These antibodies are generated using recombinant expression technologies and retain the same variable regions as their corresponding reference therapeutics, thereby preserving target specificity and binding affinity. Owing to these properties, biosimilar antibodies serve as reliable and cost-effective research reagents for applications in drug discovery, pharmacological studies, and basic biomedical research.
Research-grade biosimilar antibodies have been successfully expressed and functionally validated against a wide range of widely studied targets. These antibodies can be directly utilized as positive control reagents in drug discovery programs, as well as reference tools for rapid verification of the biological functions of target proteins in biochemical and cellular assays.
