Fig. 1 · Structure
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ASP7657 free base
EP4 Receptor Antagonist
ASP7657 free base is a potent orally active antagonist of the EP4 receptor, exhibiting binding affinities (Kis) of 2.21 nM for human EP4 and 6.02 nM for rat EP4 receptors. This compound demonstrates significant biological activity in modulating inflammatory responses and is particularly useful in research focused on conditions related to pain, inflammation, and various immune disorders. Its selective action on the EP4 receptor makes it an important tool for investigating therapeutic strategies in relevant disease models.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 1196045-28-9 |
| Applications | EP4 Receptor Antagonist |
| Formula | C28H26F3N3O3 |
| Molecular Weight | 509.52 |
| SMILES | O=C([C@H]1CC[C@H](CNC(C2=CC(C(F)(F)F)=CC3=C2N(CC4=NC5=CC=CC=C5C=C4)C=C3)=O)CC1)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.