Aspergillomarasmine A is a natural aminopolycarboxylic acid that functions as an inhibitor of class B metallo-β-lactamases (MBLs). It specifically inactivates these enzymes by chelating the essential Zn2+ cofactor, effectively promoting the degradation of zinc-deficient NDM-1 and enhancing the efficacy of β-lactam antibiotics. This compound serves as a selective Zn2+ scavenger, demonstrating broad potential for research applications aimed at understanding and overcoming β-lactam resistance in bacterial pathogens.
Aspergillomarasmine A is a natural aminopolycarboxylic acid that functions as an inhibitor of class B metallo-β-lactamases (MBLs). It specifically inactivates these enzymes by chelating the essential Zn2+ cofactor, effectively promoting the degradation of zinc-deficient NDM-1 and enhancing the efficacy of β-lactam antibiotics. This compound serves as a selective Zn2+ scavenger, demonstrating broad potential for research applications aimed at understanding and overcoming β-lactam resistance in bacterial pathogens.
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