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Asterriquinone

Antitumor Agent

Asterriquinone is a potent antitumor agent that inhibits Grb-2 binding, specifically targeting the interaction with tyrosine phosphorylated epidermal growth factor receptor (EGFR) with an IC50 of 8.37 μM. Additionally, it serves as an inhibitor of HIV-1 reverse transcriptase, exhibiting a Ki of 2.3 μM. Asterriquinone also effectively obstructs the binding activities of Grb-7 and phospholipase C-gamma (PLC-γ), making it a valuable compound for cancer and viral research applications.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	60696-52-8
Applications	Antitumor Agent
Formula	C₃₂H₃₀N₂O₄
Molecular Weight	506.59
Synonyms	ARQ; Asterriquinone SU5504
SMILES	O=C1C(O)=C(C2=CN(C(C)(C)C=C)C3=C2C=CC=C3)C(C(O)=C1C4=CN(C(C)(C)C=C)C5=C4C=CC=C5)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.