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ATX inhibitor 12

ATX inhibitor

ATX inhibitor 12 is a potent autotaxin (ATX) inhibitor, exhibiting an IC50 of 1.72 nM. This compound has demonstrated efficacy in reducing lung structural damage and minimizing fibrotic lesions in C57Bl/6J mice at an oral dose of 60 mg/kg. ATX inhibitor 12 is suitable for research applications related to idiopathic pulmonary fibrosis (IPF), facilitating studies on therapeutic strategies for this condition.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2771312-16-2
Applications	ATX inhibitor
Formula	C₃₀H₃₄FN₅O₂
Molecular Weight	515.62
SMILES	CCC1=C(N2C=C(C=C(C2=N1)C)C3=CC=C(C=C3)CN4CCC(CC4)O)NC(NCC5=CC=C(C=C5)F)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.