Fig. 1 · Structure
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ATX inhibitor 15
Autotaxin Inhibitor
ATX Inhibitor 15 is a potent inhibitor of autotaxin (ATX), featuring an indole-based carbamate structure with an IC50 of 2.17 nM. This compound effectively inhibits ATX activity in vivo and reduces the expression of pro-fibrotic factors. ATX Inhibitor 15 demonstrates protective effects on lung tissue in a bleomycin-induced fibrosis model, making it a valuable tool for research into fibrotic diseases and pulmonary health.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2484811-52-9 |
| Applications | Autotaxin Inhibitor |
| Formula | C27H32ClN5O4S |
| Molecular Weight | 558.09 |
| SMILES | O=C(NCC1=CC=C(C(Cl)=C1)OC)NC2=CN(CC)C3=C2C=C(C4=NC(CN(CCO)CCO)=CS4)C=C3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.