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ATX inhibitor 18

ATX Inhibitor

ATX Inhibitor 18 is a potent inhibitor of autotaxin (ATX), exhibiting an IC50 value of 24.2 nM. This compound demonstrates significant antiproliferative and anti-fibrotic activities, effectively suppressing collagen deposition in TGF-β-mediated cardiac fibrosis. ATX Inhibitor 18 is valuable for research applications focused on fibrosis and related cardiovascular diseases.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2402772-30-7
Applications	ATX Inhibitor
Formula	C₂₁H₁₇Cl₂FN₆O
Molecular Weight	459.30
SMILES	O=C(N1CCC2=C(C(NC3=CC=C(C(Cl)=C3)F)=NC=N2)C1)N/N=C/C4=CC=C(C=C4)Cl

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.