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Autotaxin-IN-8

Autotaxin Inhibitor

Autotaxin-IN-8 is a potent inhibitor of Autotaxin, exhibiting an IC50 of 14.2 nM against human Autotaxin. This compound effectively inhibits Autotaxin activity, leading to the modulation of MAPK activation, LPAR1, and p-ERK1/2, while also decreasing phosphorylation levels of JNK and p38. In preclinical studies, Autotaxin-IN-8 demonstrated a reduction in collagen deposition in a mouse model of pulmonary fibrosis, making it a valuable tool for research on fibrotic diseases and related pathways.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	3058084-21-9
Applications	Autotaxin Inhibitor
Formula	C₂₁H₂₀ClN₉O
Molecular Weight	449.90
SMILES	ClC1=CC=C(CCNC2=NC=C(C3=NN=C(N4CC(C5C6=CNN=N6)C5C4)O3)C=N2)C=C1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.