Fig. 1 · Structure
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Avatrombopag maleate
TPO Receptor Agonist
Avatrombopag maleate is a potent agonist of the thrombopoietin receptor (TPO), exhibiting an EC50 of 3.3 nM. This orally active compound stimulates platelet production by activating intracellular signaling pathways, thereby enhancing the proliferation of platelets and megakaryocytes from hematopoietic precursor cells. Avatrombopag maleate has applications in research focused on thrombocytopenia and blood disorders, contributing valuable insights into platelet biology and potential therapeutic strategies. Additionally, it serves as a substrate for cytochrome P450 enzymes CYP2C9 and CYP3A.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 677007-74-8 |
| Applications | TPO Receptor Agonist |
| Formula | C33H38Cl2N6O7S2 |
| Molecular Weight | 765.73 |
| Synonyms | AKR-501 maleate; E5501 maleate; YM477 maleate |
| SMILES | O=C(C1CCN(C2=NC=C(C(NC3=NC(C4=CC(Cl)=CS4)=C(N5CCN(C6CCCCC6)CC5)S3)=O)C=C2Cl)CC1)O.O=C(O)/C=C\C(O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.