- Cat. No.
- A12686
Eltrombopag
Synonyms: SB 497115
Eltrombopag is an agonist of the Thrombopoietin (Tpo) receptor, used as treatment for thrombocytopenia.
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- Cat. No.
- A13220
TA-316
Synonyms: Megakaryocytes/platelets inducing agent
Megakaryocytes/platelets inducing agent is an inducing agent for megakaryocytes and/or platelets from pluripotent stem cells, the inducing agent being useful in treating diseases involving thrombopenia.
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- Cat. No.
- A14087
Avatrombopag
Synonyms: AKR-501; YM477; E5501; AS 1670542
Avatrombopag is a novel orally-active thrombopoietin (TPO) receptor agonist.
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- Cat. No.
- A15078
Eltrombopag Olamine
Synonyms: Eltrombopag diethanolamine salt; Promacta; Revolade; SB-497115GR
Eltrombopag olamine is a new, orally active thrombopoietin-receptor (c-mpl) agonist that stimulates thrombopoiesis.
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- Cat. No.
- A16287
TPO agonist 1
TPO agonist 1 can increase production of platelets by stimulating the TPO receptor in people with chronic ITP.
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- Cat. No.
- A18089
Lusutrombopag
Synonyms: S-888711; brand name: Mulpleta.
Lusutrombopag, also known as S-888711, is an orally bioavailable, small molecule thrombopoietin (TPO) receptor agonist being developed by Shionogi for chronic liver disease (CLD) patients with thrombocytopenia prior to elective invasive surgery.
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- Cat. No.
- A36513
Avatrombopag maleate
Synonyms: AKR-501 maleate; E5501 maleate; YM477 maleate
Avatrombopag maleate is a potent agonist of the thrombopoietin receptor (TPO), exhibiting an EC50 of 3.3 nM. This orally active compound stimulates platelet production by activating intracellular signaling pathways, thereby enhancing the proliferation of platelets and megakaryocytes from hematopoietic precursor cells. Avatrombopag maleate has applications in research focused on thrombocytopenia and blood disorders, contributing valuable insights into platelet biology and potential therapeutic strategies. Additionally, it serves as a substrate for cytochrome P450 enzymes CYP2C9 and CYP3A.
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- Cat. No.
- A54492
Romiplostim
Romiplostim is a thrombopoietin (TPO) receptor (c-Mpl) agonist that acts as an Fc-peptide fusion protein mimetic of endogenous TPO. By binding to c-Mpl, Romiplostim stimulates megakaryocyte-mediated thrombopoiesis and activates similar downstream signaling pathways as natural TPO. This reagent is particularly useful for research applications involving hematopoietic acute radiation syndrome and chronic immune thrombocytopenia.
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- Cat. No.
- A65643
Avatrombopag hydrochloride
Synonyms: AKR-501 hydrochloride; E5501 hydrochloride; YM477 hydrochloride
Avatrombopag hydrochloride is a nonpeptide thrombopoietin (TPO) receptor agonist with an EC50 of 3.3 nM. It effectively mimics the biological actions of TPO, leading to enhanced platelet production by activating intracellular signaling pathways and promoting the differentiation of megakaryocytes and platelets from hematopoietic precursor cells. This compound serves as a valuable tool for research focused on disorders of thrombocytopenia and related hematological studies. Avatrombopag hydrochloride is also metabolized by cytochrome P450 enzymes CYP2C9 and CYP3A.
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- Cat. No.
- A65644
Eltrombopag methyl ester
Eltrombopag methyl ester is a potent thrombopoietin (Tpo) receptor agonist that stimulates platelet production. This compound is valuable for research applications focused on thrombocytopenia and related disorders. By activating the Tpo receptor, it plays a crucial role in understanding the mechanisms of platelet regulation and potential therapeutic strategies for enhancing platelet count.
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- Cat. No.
- A65646
Rafutrombopag diolamine
Rafutrombopag diolamine is a potent thrombopoietin receptor agonist that enhances platelet production by stimulating megakaryocyte differentiation and proliferation. This compound is primarily utilized in research related to thrombocytopenia and other platelet-related disorders, offering insights into the mechanisms of thrombopoiesis and potential therapeutic strategies. Its biological activity supports studies focused on hematological responses and related signaling pathways.
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- Cat. No.
- A65647
Totrombopag
Totrombopag is an orally active thrombopoietin receptor (TpoR) agonist. It activates TpoR, triggering an intracellular signaling cascade involving JAK2 kinase and the transcription factor Stat5, which is crucial for the regulation of megakaryocyte growth and differentiation into platelets. This compound is valuable for research into platelet production and the biology of megakaryocytes.
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- Cat. No.
- A65648
Totrombopag choline
Synonyms: SB-559448 choline
Totrombopag choline is a potent thrombopoietin receptor (TpoR) agonist that effectively stimulates megakaryocyte growth and platelet production. By activating TpoR, it triggers a signaling cascade involving JAK2 kinase and Stat5, which plays a crucial role in megakaryocyte differentiation. This compound is valuable for research focused on platelet biology and the mechanisms regulating thrombopoiesis.
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