Fig. 1 · Structure
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AVG-233
RdRp Inhibitor
AVG-233 is a potent RNA-dependent RNA polymerase (RdRp) inhibitor that effectively disrupts the initiation of the viral polymerase complex at the promoter. Its binding site is located within the L1-1749 fragment, showcasing its targeted mechanism of action. AVG-233 exhibits nanomolar activity against multiple strains of respiratory syncytial virus (RSV), with an EC50 ranging from 0.14 to 0.31 μM. This compound is a valuable tool for research focused on RSV and its associated mechanisms.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2151937-80-1 |
| Applications | RdRp Inhibitor |
| Formula | C26H22ClN5O3 |
| Molecular Weight | 487.94 |
| SMILES | O=C1N(C2=NC=CC=C2)N(CC3=CC=C(OC)C=C3)C(C1=C(C)N4CC5=NC(Cl)=CC=C5)=CC4=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.