Target & Activity
| Target | Activity | Value |
|---|---|---|
| IL-6 | ||
| IL-10 | ||
| IL-17A |
Fig. 1 · Structure
Documents & Downloads
AX-024 hydrochloride
Cat. No.
A18332
CAS
1704801-24-0
TNF receptor inhibitor
AX-024 is an orally available inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation (IC50 value 1 nM). Inhibiting an immediate TCR signal has promise for treating a broad spectrum of human T cell-mediated autoimmune and inflammatory diseases.
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Biological Activity
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1704801-24-0 |
| Applications | TNF receptor inhibitor |
| Formula | C21H23ClFNO2 |
| Molecular Weight | 375.8684 |
| Synonyms | AX-024; AX024 HCl |
| SMILES | COC1=CC(C(C2=CC=C(F)C=C2)=C(CN3CCCC3)CO4)=C4C=C1.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
| Solvent | Reported Solubility |
|---|---|
| DMSO | 64 mg/mL (170.27 mM) |
| Water | 3 mg/mL (7.98 mM) |
| Ethanol | 15 mg/mL (39.91 mM) |
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.