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AX-024 is an orally available inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation (IC50 value 1 nM). Inhibiting an immediate TCR signal has promise for treating a broad spectrum of human T cell-mediated autoimmune and inflammatory diseases.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 26.61 mL | 133.03 mL | 266.05 mL |
| 0.5 mM | 5.32 mL | 26.61 mL | 53.21 mL |
| 1 mM | 2.66 mL | 13.3 mL | 26.61 mL |
| 5 mM | 0.53 mL | 2.66 mL | 5.32 mL |
*The above data is based on the productmolecular weight 375.8684. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A18332 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 375.8684 |
| Formula | C21H23ClFNO2 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 1704801-24-0 |
| Synonyms | AX-024; AX 024; AX024 HCl; AX-024 hydrochloride |
| SMILES | COC1=CC(C(C2=CC=C(F)C=C2)=C(CN3CCCC3)CO4)=C4C=C1.[H]Cl |
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