AZD3839 free base
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Important Notice: For research use only. We do not sell to patients.
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Discription | AZD3839 (free base) is a potent and selective BACE1 inhibitor with IC50 of 23.6 uM, about 14-fold selectivity over BACE2, also a β-secretase enzyme inhibitor. |
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Catalog Num | A21606 |
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Formula | C24H16F3N5 |
Molecular Weight | 431.41 |
CAS Number | 1227163-84-9 |
SMILES | FC1=C2C([C@](C3=CC=CC(C4=CN=CN=C4)=C3)(C5=CC(C(F)F)=NC=C5)N=C2N)=CC=C1 |
Synonyms | AZD 3839, AZD-3839 |
Storage | Store lyophilized at -20ºC, keep desiccated. |
In vitro (25°C) | DMSO | 79 mg/mL (183.11 mM) | |
Water | Insoluble | ||
Ethanol | Warmed: 79 mg/mL (183.11 mM) | ||
In vivo | 5% dimethylacetamide and 20% hydroxypropyl-??-cyclodextrin in 0.3 M gluconic acid, pH 3, or 0.3 M gluconic acid, pH 3. | 1 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
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0.1 mM | 23.18 mL | 115.9 mL | 231.8 mL |
0.5 mM | 4.64 mL | 23.18 mL | 46.36 mL |
1 mM | 2.32 mL | 11.59 mL | 23.18 mL |
5 mM | 0.46 mL | 2.32 mL | 4.64 mL |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2