Fig. 1 · Structure
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(R)-Capivasertib
R-Enantiomer of Capivasertib
(R)-Capivasertib is the R-enantiomer of Capivasertib, a potent inhibitor of AKT1, AKT2, and AKT3, which are critical components of the PI3K/Akt signaling pathway. This compound exhibits significant antitumor activity by interrupting cancer cell proliferation and survival mechanisms. It is primarily utilized in research related to cancer biology, specifically for studying targeted therapies and resistance mechanisms in various malignancies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1143532-51-7 |
| Applications | R-Enantiomer of Capivasertib |
| Formula | C21H25ClN6O2 |
| Molecular Weight | 428.92 |
| Synonyms | (R)-AZD5363 |
| SMILES | O=C(C1(N)CCN(C2=C3C(NC=C3)=NC=N2)CC1)N[C@@H](C4=CC=C(Cl)C=C4)CCO |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.