Fig. 1 · Structure

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Azide-PEG3-Sulfone-PEG3-azide

PROTAC Linker

Azide-PEG3-Sulfone-PEG3-azide is a PEG-based linker designed for use in PROTAC synthesis, facilitating the creation of targeted protein degraders. This compound features an azide functional group, enabling it to engage in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it is capable of participating in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules possessing DBCO or BCN groups, making it versatile for various bioconjugation applications in chemical research.

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Specifications

Manufacturer Adooq Bioscience
CAS Number 2055024-45-6
Applications PROTAC Linker
Formula C16H32N6O8S
Molecular Weight 468.53
SMILES
[N-]=[N+]=NCCOCCOCCOCCS(CCOCCOCCOCCN=[N+]=[N-])(=O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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