Azido-PEG10-amine is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). It features an azide functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, Azido-PEG10-amine can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with entities that possess dibenzocyclooctyne (DBCO) or bicyclononyne (BCN) groups, facilitating the targeted degradation of specific proteins in biological research applications.
Azido-PEG10-amine is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). It features an azide functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, Azido-PEG10-amine can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with entities that possess dibenzocyclooctyne (DBCO) or bicyclononyne (BCN) groups, facilitating the targeted degradation of specific proteins in biological research applications.
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