Azido-PEG11-alcohol is a PEG-based linker designed for use in PROTAC (Proteolysis Targeting Chimeras) synthesis. The compound features an azide functional group, enabling its use as a click chemistry reagent through copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with dibenzocyclooctyne (DBCO) or bicyclononyne (BCN) functionalized compounds, making it a versatile tool for targeted protein degradation studies.
Azido-PEG11-alcohol is a PEG-based linker designed for use in PROTAC (Proteolysis Targeting Chimeras) synthesis. The compound features an azide functional group, enabling its use as a click chemistry reagent through copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with dibenzocyclooctyne (DBCO) or bicyclononyne (BCN) functionalized compounds, making it a versatile tool for targeted protein degradation studies.
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