Azido-PEG4-4-nitrophenyl carbonate functions as a potent linker for the creation of PROTACs, facilitating targeted protein degradation. This PEG-based compound incorporates an azide group, enabling its use in click chemistry via copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing partners. Additionally, it supports strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functionalized molecules. This reagent is valuable in chemical biology studies focused on targeted therapeutics and protein manipulation.
Azido-PEG4-4-nitrophenyl carbonate functions as a potent linker for the creation of PROTACs, facilitating targeted protein degradation. This PEG-based compound incorporates an azide group, enabling its use in click chemistry via copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing partners. Additionally, it supports strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functionalized molecules. This reagent is valuable in chemical biology studies focused on targeted therapeutics and protein manipulation.
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